A New Norcembranoid Dimer from the Red Sea Soft Coral Sinularia gardineri
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 59 (7) , 687-689
- https://doi.org/10.1021/np960207z
Abstract
A study of Sinularia gardineri (Pratt) (Alcyoniidae), collected in the Red Sea, revealed a new heptacyclic norcembranoid dimer singardin (1). The structure of singardin was deduced by spectroscopic analysis. A known sesquiterpene, guaianediol (2), and the known cembranolides (1R,5S,8R,10S,11R)-11-hydroxy-1-isoprenyl-8-methyl-3,6-dioxo-5,8-epoxycyclotetradec-12-ene 10,12-carbolactone (5-epi-sinuleptolide) and sinuleptolide were also isolated. Compounds 1 and 2 show cytotoxicity to murine leukemia (P-388), human lung carcinoma (A-549), human colon carcinoma (HT-29), and human melanoma cells (MEL-28).Keywords
This publication has 8 references indexed in Scilit:
- Potent Inhibitors of Histamine Release: Polyhydroxylated Sterols from the Okinawan Soft CoralSinularia abruptaJournal of Pharmaceutical Sciences, 1994
- A Novel Norditerpenoid from the Okinawan Soft Coral Sinularia Sp.Journal of Natural Products, 1993
- Studies of Australian Soft Corals, XLIX. A New Biscembranoid and Its Probable Biosynthetic Precursors from the Soft Coral Sarcophyton tortuosumJournal of Natural Products, 1993
- A farnesyl arabinoside as an enhancer of glucose transport in rat adipocytes from a soft coral,Sinularia sp.Cellular and Molecular Life Sciences, 1992
- A novel chlorinated biscembranoid from the marine soft coral Sarcophyton glaucumThe Journal of Organic Chemistry, 1990
- Fijiensin, the first phytotoxin fromMycosphaerella fijiensis, the causative agent of Black Sigatoka diseaseCellular and Molecular Life Sciences, 1990
- Flowing afterglow negative ion photoelectron spectroscopy of dirhenium. Evidence for multiple bonding in Re2 and Re2-Journal of the American Chemical Society, 1986
- Norcembrene diterpenoids from pacific soft-corals of the genus sinularia (Alcyonacea; octocorallia)Tetrahedron, 1985