Hemostatic Effectiveness of Platelets Stored at 22°C

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Abstract
Storage of platelets at 22 rather than 4°C improves both 51Cr recovery and platelet life-span measurements. The functional state of such platelets after transfusion was studied in normal volunteers treated with aspirin to prolong bleeding time and impair platelet aggregation. Transfusion of fresh platelets to equal more than 10 per cent of the total immediately shortened the bleeding time and restored the platelet aggregation patterns to normal. The aggregation patterns of platelets deteriorated during storage in bags at 22°C. Within 24 hours after transfusion of platelets previously stored for 24 to 48 hours at 22°C, both bleeding time and aggregation patterns were restored toward normal. The observation that after transfusion to aspirin-treated volunteers normal aggregation returned suggests improvement in platelet function after transfusion. Return of normal aggregation in vivo was better for platelets stored at 22°C for only 24 hours than for platelets stored at 22°C for 48 hours.