COMPARATIVE STUDIES OF ANTITUMOR EFFECT ON INTRAVENOUS ADMINISTRATION OF CARBAZILQUINONE AND MITOMYCIN-C

  • 1 January 1976
    • journal article
    • research article
    • Vol. 67  (6) , 805-812
Abstract
A comparison between carbazilquinone and mitomycin C, both of which contain aziridinyl, carbamoyloxy and quinonyl groups, was made for their therapeutic effect on i.v. administration. Although both agents exhibited a significant effect on plasmacytoma X5563 in C3H/He mice to a similar extent, mitomycin C was not as effective in lympholeukemia L-1210 and lung metastases of Ehrlich carcinoma in (C57BL/6 .times. DBA/2)F1 (BDF1) mice as carbazilquinone. Possible interpretations regarding this discrepancy are discussed.

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