Synthesis of 3β-methoxy-5α, 14α-card-20(22)-enolide from 3β-methoxy-5α-androstan-17-one. A method for the construction of the cardenolide slide-chain
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 1,p. 25-26
- https://doi.org/10.1039/c39810000025
Abstract
The Cardenolide side-chain has been constructed on the androstane skeleton via Knoevenagel condensation of the 17-oxo-derivative (2a) with ethyl cyanoacetate, three-step transformation of the resultant product (2b) to the protected hydroxy-aldehyde (4), followed by the formation of the cyanohydrin (5a), hydrolytic butenolide ring closure, and dehydration.Keywords
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