RENAL TUBULAR DYSFUNCTION IN RHEUMATIC DISEASES
- 1 April 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 30 (2) , 115-118
- https://doi.org/10.1093/rheumatology/30.2.115
Abstract
Evidence of renal tubular dysfunction as defined by abnormal urinary levels of α and β2 microglobulin with or without microalbuminuria was found in 47 (16.5%) of 285 patients with a variety of rheumatic diseases, compared with a preva lence of <1% in 500 healthy adults. Previous work from this unit has shown a prevalence of tubular dysfunction of 24% in patients with severe rheumatic disease admitted to hospital, probably associated with severe rheumatoid arthritis. Although our study confirms a high prevalence of renal tubular dysfunction, we have shown that it is related to age and intercurrent illness, particularly urinary tract infection, rather than to rheumatic disease or drug therapy, although it is possible drug therapy could add to a compound insult on an ageing or damaged kidney.Keywords
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