Spin label synthesis using NN′-thionyldiimidazole coupling reagent

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Abstract
Spin-labelled esters of both cortisol and testosterone have been synthesized using the coupling reagent NN′-thionyldiimidazole (1); use of more conventional coupling or dehydrating reagents failed to give these spin labels, suggesting that (1) may be useful in the esterification of other hindered, relatively unreactive alcohols.