Basophilic Differentiation of Chronic Myelogenous Leukaemia Cells in Vitro
- 1 October 1977
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 19 (4) , 321-326
- https://doi.org/10.1111/j.1600-0609.1977.tb01481.x
Abstract
Peripheral leucocytes from 10 patients with chronic myelogenous leukaemia (CML) were cultured in liquid medium and observed morphologically for 6 to 10 weeks. All cultures showed an increased proportion of mature basophils at about 3 weeks and most cultures consisted predominantly of mature basophils at about 5 weeks. The results indicate preferential basophilic differentiation of CML leucocytes in vitro and are consistent with basophilia frequently observed in CML patients.Keywords
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