The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition
- 1 January 2006
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 387 (6) , 707-14
- https://doi.org/10.1515/bc.2006.089
Abstract
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.Keywords
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