Diphtheria Antitoxin: Antigen-Combining and Toxin-Neutralizing Properties of Papain Fragments

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Abstract
Papain-digested rabbit antibodies to diphtheria toxoid were separated into three fragments. Fragments I and II combined with toxoid in vitro and neutralized toxin. The ratios of these activities were not the same for fragments I and II, indicating that antitoxic and accessory antibody may be distributed unequally between two classes of antibody.