A Comparison of Penicillin-producing Strains of Penicillium notatum-chrysogenum

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Abstract
The penicillin-producing properties and the gross metabolic characteristics of a number of strains of the P. notatum-chrysogenum group were compared. The fermentations were conducted in 100-gallon tanks on a medium consisting of 3-4% lactose, 4% steep liquor solids, and 1% CaCO3. Air was supplied at a rate of 200 l./min. The conditions, aside from adequate aeration, apparently necessary for optimum penicillin production are rapid initial production of mycelium, the presence of a slowly fermentable carbohydrate and available N (e.g., ammonia), and the maintenance of a pH value between 7 and 7.8. The penicillin yield under these conditions varies widely with the culture used. Of the many strains tested, the mutant P. chrysogenum strains X-1612 and Q176 have been found to produce the highest yields. Strain X-1612 yields 400 to 500 U./ml., and strain Q176 gives 700 to 900 U./ml.

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