Gamma Interferon‐Induced Specific Binding of Tetanus Toxin on the GG2EE Macrophage Cell Line
- 31 August 1990
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 32 (3) , 289-292
- https://doi.org/10.1111/j.1365-3083.1990.tb02922.x
Abstract
We have recently demonstrated that tetanus toxin (TT) selectively inhibited gamma interferon-(IFN-.gamma.)-induced, but not basal, lysozyme activity in the GG2EE macrophage cell line. By an indirect immunofluorescence technique, we show that tetanus toxin, as well as the BIIb tetanus toxin-derived fragment, selectively binds to IFN-.gamma.-treated cells but fails to bind to control cells. Moreover, BIIb fragment and TT share the same binding sites, as demonstrated by competition/displacement experiments. These data indicate that IFN-.gamma. pretreatment results in the acquisition of tetanus toxin binding sites on GG2EE cells by a mechanisms(s) yet to be identified.This publication has 7 references indexed in Scilit:
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