Triglyceride lipases and atherosclerosis
- 1 October 2010
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Lipidology
- Vol. 21 (5) , 409-415
- https://doi.org/10.1097/mol.0b013e32833ded83
Abstract
There are several ways by which derangement of the lipases may contribute to atherogenesis. Lipase actions are major determinants of plasma lipoprotein patterns. LPL activity must be modulated in relation to the physiological situation (feeding, fasting, exercise, etc.). Fatty acids and monoglycerides generated must be efficiently removed so that they do not endanger the integrity of the endothelium, cause lipotoxic reactions or both. In addition, the lipases may cause binding and endocytosis of lipoprotein particles in the artery wall.Keywords
This publication has 89 references indexed in Scilit:
- GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into CapillariesCell Metabolism, 2010
- Lipase Maturation Factor LMF1, Membrane Topology and Interaction with Lipase Proteins in the Endoplasmic ReticulumPublished by Elsevier ,2009
- Identification of the Active Form of Endothelial Lipase, a Homodimer in a Head-to-Tail ConformationPublished by Elsevier ,2009
- Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)Journal of Biological Chemistry, 2009
- Variation in ANGPTL4 and risk of coronary heart disease: the Atherosclerosis Risk in Communities StudyMetabolism, 2008
- The interferon-γ-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3Cellular Signalling, 2008
- Expression of carboxylesterase and lipase genes in rat liver cell-typesBiochemical and Biophysical Research Communications, 2008
- Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 Plays a Critical Role in the Lipolytic Processing of ChylomicronsCell Metabolism, 2007
- Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDLNature Genetics, 2007
- Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissueProceedings of the National Academy of Sciences, 2006