Suppression of Local Tissue Reactivity (Shwartzman Phenomenon) by Nitrogen Mustard, Benzol, and X-Ray Irradiation

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Abstract
The Schwartzman phenomenon was studied in rabbits using a meningococcus filtrate and meningococcus endotoxin. The following agents were without suppressive effect on the Schwartzman phenomenon: benadryl, ure-thane, crude penicillin extract, penicillin G, streptomycin, ma-pharsen, BAL, vitamin C, alpha tocopherol, thyroidectomy, and partial exsanguination. The reaction was completely suppressed by pretreatment of the rabbits with nitrogen mustard or benzol. It was also completely suppressed in some rabbits and partially in others by pretreatment with total body X-ray irradiation. It is suggested that this study provides an exptl. basis for a new therapeutic concept in the treatment of diseases involving tissue and vascular reactivity.