Monoterpenic fragment analogs of aplasmomycin as potential antimalarials
- 1 September 1991
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 34 (9) , 2821-2823
- https://doi.org/10.1021/jm00113a021
Abstract
Seven analogues of monoterpenic fragment of aplasmomycin were synthesized as targeted antimalarial agents. The potency of the compound 6 was comparable with the sesquiterpene lactone artemisinin and the antibiotic aplasmomycin in vivo against Plasmodium berghei yoelli.Keywords
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