Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses
Top Cited Papers
- 11 December 2005
- journal article
- clinical trial
- Published by Springer Nature in Nature Neuroscience
- Vol. 9 (1) , 23-25
- https://doi.org/10.1038/nn1616
Abstract
Trial-to-trial variability in the blood oxygen level–dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.Keywords
This publication has 14 references indexed in Scilit:
- The human brain is intrinsically organized into dynamic, anticorrelated functional networksProceedings of the National Academy of Sciences, 2005
- Quantitative prediction of perceptual decisions during near-threshold fear detectionProceedings of the National Academy of Sciences, 2005
- Small modulation of ongoing cortical dynamics by sensory input during natural visionNature, 2004
- Neuronal correlates of perception in early visual cortexNature Neuroscience, 2003
- Neural Correlates of Visual Working Memory: fMRI Amplitude Predicts Task PerformancePublished by Elsevier ,2002
- Detection of functional connectivity using temporal correlations in MR imagesHuman Brain Mapping, 2002
- Functional Connectivity in Single and Multislice Echoplanar Imaging Using Resting-State FluctuationsNeuroImage, 1998
- Dynamics of Ongoing Activity: Explanation of the Large Variability in Evoked Cortical ResponsesScience, 1996
- Emergence of order in visual system development.Proceedings of the National Academy of Sciences, 1996
- Functional connectivity in the motor cortex of resting human brain using echo‐planar mriMagnetic Resonance in Medicine, 1995