Effect of Tetracycline on a Standardized Intracutaneous Staphylococcal Infection in Guinea Pigs.

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Abstract
Summary Administration of tetracycline markedly lowered the charge of tetracycline-resistant staphylococci required to initiate a standardized intracutaneous lesion in guinea pigs. The results were independent of the route of antimicrobial administration. Tetracycline administered before and during the course of an infection with tetracycline susceptible staphylococci appeared inconstantly to increase the infectious charge required to establish the lesion. The mechanisms underlying these observations are not understood.

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