Levels of Piribedil and its Active Metabolite (S-584) in the Rat Striatum
- 1 January 1975
- journal article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (10) , 595-600
- https://doi.org/10.3109/00498257509056129
Abstract
1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.Keywords
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