Molecular Basis of Colorectal Cancer
Top Cited Papers
- 17 December 2009
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 361 (25) , 2449-2460
- https://doi.org/10.1056/nejmra0804588
Abstract
This review gives an account of recent advances in our knowledge of the molecular mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic mutations, occur in familial syndromes of colorectal cancer, whereas somatic mutations are the outstanding feature of sporadic colorectal cancer. Genetic changes drive the progression from adenoma to carcinoma and probably influence individual susceptibility and response to treatment.Keywords
This publication has 123 references indexed in Scilit:
- Sensitive digital quantification of DNA methylation in clinical samplesNature Biotechnology, 2009
- Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21Nature Genetics, 2008
- A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3Nature Genetics, 2008
- The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch Syndrome: from bench to bedsideFamilial Cancer, 2007
- Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24Nature Genetics, 2007
- A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21Nature Genetics, 2007
- CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancerNature Genetics, 2006
- RAF/RAS oncogenes and mismatch-repair statusNature, 2002
- Mutations of the BRAF gene in human cancerNature, 2002
- Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancerNature, 1994