Plasma concentrations of endothelin in man: arterio‐venous differences and release during venous stasis

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Abstract
Endothelin‐1 is a recently described endothe‐lium‐derived vasoconstricting peptide. Plasma concentrations of immunoreactive (IR‐) endothelin were investigated in six healthy young men applying a radioimmunoassay after extraction of endothelin from plasma. In venous plasma a mean concentration of 1.3 pM; 0.4 pmol 1‐1 was found, whereas the mean concentration in arterial plasma was 0.9 pM; 0.4 pmol 1‐1 (p< 0.005). During venous stasis for 10 min the mean plasma concentration of IR‐endothelin increased about twofold, from basal 1.1pM;0.3 pmol l‐1 to 2.1pM;0.3 pmol 1‐1 (pin vivo under a variety of pathological conditions.