Sulphur in epidermal keratohyalin granules: A quantitative assay by x-ray microanalysis

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Abstract
The elemental composition of different types of keratohyalin granules of newborn and adult rat epidermis was studied by EM. An absolute quantitation of the S concentration in keratohyalin granules was performed. The epidermal keratohyalin granules were chemically heterogeneous. Single granules, a type of keratohyalin granule present in the nuclei and cytoplasm of epidermal cells from both newborn and adult rats, were rich in S, containing 2.5-3.6% S. Other types of keratohyalin granules, which differ in newborn and adult rats, contained a S-poor component; but they often had a S-rich component as well. The S-poor keratohyalin contained 0.6-0.9% S.

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