The Effect of Microwave Radiation on Binding of Propyl-2,3-[3H]-Dehydroalprenololto β-Adrenergic Receptors of Rat Erythrocyte Membranes

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Abstract
The effect of microwave radiation (2450 MHz) on binding of the ligand propyl-2,3-[3H]-dehydroalprenolol to β-adrenergic receptors of rat erythrocyte membranes has been studied. It is shown that microwave exposure decreases specific binding of the ligand to receptors. The effect is dependent on time of exposure (66.2% on 10 min exposure and 37.3% on 30 min exposure). EDTA and heparin used as anticoagulants do not significantly alter the experimental results. However, the Ca2+ content in the incubation medium is essential for the effect. Exposure of erythrocytes isolated in the presence of EDTA and incubated in Hanks' solution without CA2+ has no effect on binding. The effect is manifest when Ca2+ is added to the specimen exposed. Possible mechanisms of action of microwaves on the studied parameter are discussed.