Kinetic resolution of 1,2-diols with D-camphorquinone; preparation of (R)-(chloromethyl)oxirane
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 1600-1602
- https://doi.org/10.1039/c39840001600
Abstract
Acid-catalysed reaction of D-camphorquinone with racemic 1,2-diols (e.g. 3-chloropropane-1,2-diol)under kinetically controlled conditions yields a predominant diasteroisomeric acetal, that can be easily converted into an optically pure epoxide.Keywords
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