ALLERGY TO VIRAL AND RICKETTSIAL VACCINESII. Allergic Reactions Encountered and Further Studies with Refined Influenza and Mumps Vaccines in Allergic Children
- 1 May 1952
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine
- Vol. 83 (5) , 608-617
- https://doi.org/10.1001/archpedi.1952.02040090054005
Abstract
BECAUSE of the avidity that rickettsiae and viruses have for embryonal tissues, the chick embryo was found to be a desirable culture medium for the preparation of immunizing vaccines. The vaccines which are considered of value as immunizing agents are yellow fever, typhus, Rocky Mountain spotted fever or tick typhus, equine encephalomyelitis, influenza A and B strains of virus, and mumps. However, allergic reactions have resulted as a side-effect from the use of such vaccines in egg-sensitive persons. Injection of egg protein, as a diagnostic procedure, in exquisitely sensitive children has resulted in profound anaphylactic-shock reactions1and death.2How frequently one may expect to encounter such persons was estimated by us in previous reports.3We found that 20% of 500 allergic children3cdemonstrated a dermal sensitivity to egg proteins. In only 5% was this sensitivity of clinical significance. We propose in this study to analyze andKeywords
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