α-Amylase (EC 3.2.1.1) susceptibility rather than viscosity or gastric emptying rate controls plasma responses to starch in healthy humans

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Abstract
The relationship between starch -amylolysis was 48 (sd 4)% for S24 and 35 (sd 4)% for S50. Test meals differed in viscosity (mPas: S24, 54000; S50, 190; GS, 4). Carbohydrates were labelled with 99mTechnetium and isotope gastric emptying was measured by external gamma counting. Carbohydrate isotopic gastric emptying patterns were exponential. Half gastric emptying time (min) was significantly (P < 0.05) shorter for S50 (19 (sd 2)) than for GS (26 (sd 2)) or S24 (29 (sd 2)). No correlation was found between half gastric emptying time and plasma response values. Values for peak insulin (pmol/l) above fasting were significantly (P < 0.05) different: GS, 306 (sd 11); S24, 227 (sd 11); S50, 187 (sd 11). It is concluded that α-amylase susceptibility of the test carbohydrates is a determining factor in the insulin response of healthy subjects, while viscosity of the test meals and gastric emptying rate have no effect.