Alterations in Tissue and Serum Aldolase in Rabbits Due to Vitamin E Deficiency

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Abstract
Dystrophic rabbit muscle showed a decrease in total nitrogen, noncollagen nitrogen (NCN), dry weight and dry fat-free weight (DFF wt). Collagen nitrogen and the fat content of the tissue were found to be increased over that seen in the controls. Livers of E-deficient animals displayed a 40% rise in total nitrogen and NCN versus normals. Aldolase activity was markedly decreased in dystrophic muscle, but liver revealed an elevation in its enzyme concentration compared to controls. The elevation of serum aldolase in E-deficient rabbits preceded and paralleled the creatinuria associated with the development of dystrophy by a period of 1 to 2.5 weeks. These conclusions were compared to those observed in other forms of muscle wasting.

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