Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis.
Open Access
- 1 May 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 128 (5) , 2358-2361
- https://doi.org/10.4049/jimmunol.128.5.2358
Abstract
It is well established that immune potential declines with age and that aged animals are unable to mount vigorous cell-mediated immune responses. Production of the lymphokine, Interleukin 2 (IL 2) in response to the T cell mitogen concanavalin A or allogeneic stimulation is also diminished in aged individuals. This lesion in IL 2 synthesis in aged mice underlies their deficiency in cell-mediated responses. Mixed lymphocyte responses, cell-mediated lympholysis, and antigen-induced T cell proliferation are all markedly enhanced by supplementation with this lymphokine.This publication has 18 references indexed in Scilit:
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