Amish study, V: Lithium-sodium countertransport and catechol O- methyltransferase in pedigrees of bipolar probands

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Abstract
Individuals (87) from 4 large Amish pedigrees were studied to determine the relationship between susceptibility to affective disorders and variation in the measures of 2 biochemical variables, catechol O-methyltransferase (COMT) and Li countertransport. Assays were done in duplicate and blind to diagnostic or pedigree status. Data were analyzed separately within families as well as by pooling ill and well subjects across pedigrees. Various statistical analyses yielded no significant differences in Li measures or COMT activity levels between members diagnosed as having a form of affective disorder and normal members.