NODULÄRE HYPERPLASIE UND ADENOME DES HYPOPHYSENVORDERLAPPENS BEI HYPOTHYREOSE

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Abstract
Autopsies were performed on three older patients, two with primary myxoedema and one cretin, who had received little or no thyroxine treatment. The anterior lobe of the pituitary gland showed hypertrophy and nodular hyperplasia of the sparsely granulated mucoid cells (which could be characterized partly as S2-, delta-, gamma-, beta2-cells) and the large chromophobes and even in two cases adenomas. There is probably a relation between these changes in the pituitary gland and the hypothyroidism. The few published cases of pituitary adenomas in the presence of primary hypothyroidism are tabulated. The development of hyperplastic and adenomatous changes is chiefly explained as a consequence of a decrease in the feedback of thyroid hormone to the pituitary gland and the hypothalamic centres resulting in a hyperstimulation of the TSH-producing cells. The relative rarity of nodular hyperplasia and adenomas in connection with long standing hypothyroidism is not yet clear.

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