Some characteristic features of the biotransport of the cytostatic agent 1,6‐dibromo‐1,6‐dideoxy‐dulcitol
- 15 January 1967
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 2 (1) , 21-25
- https://doi.org/10.1002/ijc.2910020105
Abstract
Aspects of the biological transport of cytostatically active 1,6‐dibromo‐1,6‐dideoxydulcitol (DBD) were studied using 82Br‐labelled material on dogs and Yoshida tumorbearing rats. Thirty‐five per cent of the DBD dose was excreted in the urine within 12 hours. Besides unchanged DBD, metabolites containing C‐Br bonds could also be detected in the urine. In vivo, the 50% decomposition time of the C‐Br bonds in DBD is about 5 to 6 hours. One hour after administration of DBD, more than 50% of the persisting dose had entered the cells. Accumulation of the drug in the tumor tissue could not be demonstrated. A fraction of the dose enters the enterohepatic circulation.This publication has 2 references indexed in Scilit:
- 1,6-Dibromo-1,6-dideoxy-dulcitol: a New Antitumoral AgentNature, 1967
- A comparison of the distribution of some halide ions in the bodyBiochemical Pharmacology, 1964