Does endogenous prostaglandin affect gastric antral motility?

Publisher Website
Google Scholar
Abstract
Intracellular electrical activity and muscle contraction were recorded simultaneously from circular muscle of the canine antrum. Treatment with indomethacin enhanced the plateau phase of the spontaneously occurring gastric action potential and the amplitude of the phasic contraction. Exogenous PG[prostaglandin]E2 reversed this effect of indomethacin. Treatment with indomethacin also enhanced the electrical and mechanical responses to pentagastrin; this enhancement was also reversed by PGE2. Endogenous prostaglandin, probably of the E series, tonically suppresses the spontaneous electrical and mechanical activities of antral circular muscle and the responsiveness of the muscle to excitatory stimuli.