Rheumatoid arthritis association at 6q23
Top Cited Papers
- 4 November 2007
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 39 (12) , 1431-1433
- https://doi.org/10.1038/ng.2007.32
Abstract
This is an issue edsumm for 32. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming. The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 × 10−8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α–induced protein 3 (TNFAIP3).Keywords
This publication has 13 references indexed in Scilit:
- Risk Alleles for Multiple Sclerosis Identified by a Genomewide StudyNew England Journal of Medicine, 2007
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature, 2007
- Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patientsRheumatology, 2006
- A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullinationArthritis & Rheumatism, 2005
- Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: Further support that PTPN22 is an autoimmunity geneArthritis & Rheumatism, 2005
- The basic helix–loop–helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cordProceedings of the National Academy of Sciences, 2005
- Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: Evidence for an early onset/disease severity effectArthritis & Rheumatism, 2005
- The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responsesNature Immunology, 2004
- De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signallingNature, 2004
- Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient MiceScience, 2000