Effect of Moderate Levels of Dietary Fish Oil on Insulin Secretion and Sensitivity, and Pancreas Insulin Content in Normal Rats

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Abstract
The effect of ω-3 fatty acids derived from fish and marine mammals on subjects with normal glucose tolerance is still unclear. The aim of the present study was to test whether the hypolipidemia that follows the chronic administration of cod liver oil, rich in polyunsaturated fatty acids (ω-3), to normal rats is accompanied by changes in glucose metabolism, insulin secretion and sensitivity, and pancreatic insulin content. To achieve this goal, male Wistar rats were fed with a semisynthetic diet (w/w): 62.5% cornstarch, 7% cod liver oil plus 1% corn oil, and 17% protein (CD + CLO). Control rats were fed with the same semisynthetic diet with the only exception that the source of fat was 8% (w/w) corn oil (CD). Both diets were administered adlibitum for 1 month. At the end of the experimental period, the results obtained were as follows (mean ± SEM): serum triacylglycerol (mM): CD + CLO 0.21 ± 0.04 vs. CD 0.58 ± 0.05 (p

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