Infection and Lymphoma

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Abstract
The persistence of the eponyms “Hodgkin” and “Reed–Sternberg” and the noncommittal descriptor “disease” underscores the uncertainties long associated with the multinucleated giant cells that Sternberg believed to be a manifestation of infection and Reed believed to be malignant. In fact, it is now clear that several infections are closely linked with lymphomagenesis. These include Epstein–Barr virus (EBV) in a variety of lymphoproliferative diseases, human T-cell leukemia virus type 1 (HTLV-1) in adult T-cell leukemia–lymphoma, Helicobacter pylori in gastric mucosa-associated lymphoid-tissue lymphoma, and hepatitis C virus in splenic lymphoma with villous lymphocytes.Broadly speaking, the infectious agents associated with lymphoma fall . . .