Structure-activity relationship in PAF-acether. 2. RAC-1-O-octadecyl-2-O-acetyl-3-O-[.gamma.-(dimethylamino)propyl]glycerol
- 1 August 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 28 (8) , 1094-1096
- https://doi.org/10.1021/jm00146a019
Abstract
Two products without phosphoryl groups, 1-O-octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol and its quaternary salt, were synthesized from 1-O-octadecyl-2-O-benzylglycerol. In comparison with PAF-acether, they lost aggregating and bronchoconstrictive activities and did not show any antagonistic effects.Keywords
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