Dissociation of innate susceptibility to Salmonella infection and endotoxin responsiveness in C3HeB/FeJ mice and other strains in the C3H lineage

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Abstract
Studies of various mouse strains in the C3H lineage indicated that there is no correlation between innate susceptibility to Salmonella infection and sensitivity to the toxic or mitogenic effects of lipopolysaccharide (LPS). C3H/HeNCrlBR mice were Salmonella resistant, but sensitive to the toxic and mitogenic effects of LPS; C3H/HeJ mice were Salmonella susceptible, but LPS unresponsive. C3HeB/FeJ mice were as Salmonella susceptible as the C3H/HeJ mice, yet were mitogenically responsive to LPS and sensitive to its lethal effects. Other mouse strains (C3H/HeTex and C3H/HeDub) displayed intermediate susceptibility to Salmonella infection and were responders to the mitogenic and toxic effects of LPS. Thus, endotoxemia evidently cannot be a major factor in the pathogenesis of Salmonella infection. The involvement of multiple factors in the control of innate resistance to Salmonella infection in mice of the C3H lineage was indicated.