On the purinergic system in rat duodenum : existence of P1and P2receptors on the smooth muscle
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Archives Internationales de Physiologie et de Biochimie
- Vol. 98 (1) , 53-58
- https://doi.org/10.3109/13813459009115737
Abstract
In rat duodenum, in vitro, in the presence of atropine and guanethidine, ATP administration caused a tetrodoxin-insensitive relaxation followed by a rebound contraction. A similar response was obtained also after electrical field stimulation (EFS) of non-adrenergic, non-cholinergic (NANC) nerves, α, β-methyleneATP and theophylline antagonized the response to ATP, but they failed to affect the noradrenaline- and EFS-induced relaxation. These results suggest that P1 and P2 receptors are present in rat duodenum, but their activation is not responsible for the inhibitor effects due to the NANC nerves.This publication has 9 references indexed in Scilit:
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