The Effect of Inhibitors of Glycosylation on Interferon Production in Human Lymphoblastoid Cells

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Abstract
Summary Interferon production was inhibited in the Namalwa line of human lymphoblastoid cells by treatment with 2-deoxy-d-glucose or d-glucosamine. d-Glucosamine also inhibited protein synthesis and the cells were no longer viable, whereas 2-deoxy-d-glucose allowed protein and RNA synthesis to continue at control rates, and the cells remained fully viable. It is concluded that a glycosylation step is essential for production of lymphoblastoid interferon.