Pentagastrin Stimulation of DNA Synthesis and Thymidine Kinase Activity in Gastric Mucosa of Rats

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Abstract
Following four equally spaced injections (at 12-hour intervals) of pentagastrin (250 µg/kg) to fasted rats the incorporation of [3H]-thymidine into gastric mucosal DNA in vivo and in vitro was significantly increased by 30 and 58%, respectively, when compared with the corresponding saline control. Pentagastrin treatments also caused a significant 50% enhancement in gastric mucosal thymidine kinase activity. It is suggested that the hormone-mediated stimulation in thymidine kinase activity may, in part be due to the presence of a physiological activator for the enzyme in the tissue.