TUMOR-MARKER PRODUCTION IN HUMAN BRONCHIAL-CARCINOMA XENOGRAFTS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 3  (4) , 273-281
Abstract
A total of 37 human bronchial carcinomas (15 small cell, 10 squamous, 6 large cell and 6 adenocarcinomas) were successfully heterotransplanted into immune-suppressed mice. Monolayer tissue cultures were established from 23 of the xenograft lines. After contact with tumor cells, supernatant culture medium was analyzed by radioimmunoassay for ACTH, calcitonin, human chorionic gonadotrophin .beta. subunit (.beta.HCG) and carcinoembryonic antigen (CEA). Calcitonin production was associated with 3 (13%) xenograft lines (2 small cell, 1 adenocarcinoma). .beta.HCG was found in 3 (13%) lines (1 small cell, 2 large cell anaplastic). CEA was produced in 13 (56.5%) lines (7 small cell, 2 squamous, 1 large cell, 3 adenocarcinomas). ACTH was present in 18 (78.2%) lines (11 small cell, 2 squamous, 2 large cell, 3 adenocarcinomas), but evidence indicates that this hormone is not in all cases produced and secreted by the tumor.

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