Effect of Estrogen-Treatment and Castration on ACTH Content of Rat Adenohypophysis.

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Abstract
(1) The ACTH content of the pituitaries of estrogen-treated and castrated male rats was assayed against that of controls by the adrenal ascorbic acid-depletion method. (2) The estrogen-hypophyses were found to contain 75% and those of the castrates 63% of the amount of ACTH encountered in the controls. (3) Since no parallelism was observed between the ACTH content and the amount of delta granules present in these pituitaries, it is concluded that adenohypo-physial ACTH is not associated with the delta granules. (4) Further histophysiological and physiological implications of these findings are discussed.