Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDS
- 24 August 1984
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4664) , 840-842
- https://doi.org/10.1126/science.6206563
Abstract
Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg 2+ -dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.Keywords
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