The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs
Open Access
- 1 May 1986
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 88 (1) , 149-153
- https://doi.org/10.1111/j.1476-5381.1986.tb09481.x
Abstract
1 The release of platelet-activating factor (Paf-acether) and of its inactive precursor/metabolite lysoplatelet activating factor (lyso-Paf) from control and sensitized guinea-pig isolated lungs challenged with antigen was investigated. 2 Control guinea-pig lungs perfused either through the pulmonary circulation or through the airways and challenged with antigen did not release Paf-acether. 3 Sensitized guinea-pig isolated lungs perfused through the pulmonary circulation and challenged with antigen released lyso-Paf but not Paf-acether. 4 Sensitized guinea-pig isolated lungs perfused through the airways and challenged with antigen released three times more lyso-Paf and also Paf-acether. 5 These results support a possible role for Paf-acether in respiratory anaphylaxis in the guinea-pig.This publication has 28 references indexed in Scilit:
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