Synthesis of 5-Benzyl and 5-Benzyloxybenzyl 2,2′-Anhydrouridines and Related Nucleoside Analogs as Inhibitors of Uridine Phosphorylase
- 1 February 1988
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 7 (1) , 91-102
- https://doi.org/10.1080/07328318808068705
Abstract
Furanosyl analogs of BAU (5-benzylacyclouridine) and BBAU (5-benzyloxybenzylacyclouridine), two potent inhibitors of uridine phosphorylase, were synthesized and evaluated as potential cancer chemotherapeutic agents. The analogs included ribosides, 2,2′-anhydro nucleosides, arabinosides and deoxyribosides. The anhydrouridine intermediates were potent inhibitors of uridine phosphorylase and good potentiators of FdUrd activity in human tumor cells in culture.This publication has 11 references indexed in Scilit:
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