IL-1β and TNFα, but not IL-6, induce α1- antichymotrypsin expression in the human astrocytoma cell line U373 MG

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Abstract
Cytokines such as interleukin-1 (IL-1) and interleukin-6 (IL-6) have previously been shown to participate in neurodegenerative processes including Alzheimer's disease. However, the molecular consequences of increased cytokine expression in the brain remain largely unknown. We have studied the effects of IL-1, IL-6 and TNFα on the expression of the acute-phase protein α1-antichymotrypsin (ACT) in human astrocytoma cell lines. Both IL-1 and TNFα, but not IL-6, were able to induce ACT gene transcription and protein synthesis. The synthetic glucocorticoid dexamethasone enhanced cytokine-induced ACT mRNA expression and protein synthesis. We conclude that IL-1-induced expression of ACT may be part of the inflammatory response in the brain and may be involved in the pathology of Alzheimer's disease.

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