THE OCCURRENCE OF TWO DIFFERENT GLUTAMIC DEHYDROGENASES IN NEUROSPORA

Abstract
Many wild-type strains of Neurospora crassa produce two glutamic dehydrogenases, one specific for triphosphoryrldlne nucleotlde and another for diphos-phopyrldlne nucleotide. The enzymes have been separated from one another and purified about 50-fold. Michaelis constants have been reported for various substrates. The pH optima of the DPN- and TPN-speciflc enzymes are 8.3 and 7.5 respectively. The possible reasons for the presence of two different enzymes catalyzing the same reaction are discussed.