Abstract
The I in the blood of 21 euthyroid and 28 hyperthyroid persons was fractionated by means of butanol extraction and salt fractionation. Seventy-five percent of the protein-bound iodine (PBI) was found to be butanol extract-able and seemed to exist in two different states with a normal ratio of 1 : 1. One part was bound to globulin; the other to albumin. The latter complex, consisting of organic I in a free or peptide form, was found to be the part responsible for the rise in PBI in hyperthyroidism. It was suggested that only the I albumin complex was dissociable and hence, capable of governing the basal metabolic rate.

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