Jejunal water and electrolyte secretion induced by L-arginine in man.
- 1 February 1981
- Vol. 22 (2) , 108-113
- https://doi.org/10.1136/gut.22.2.108
Abstract
In this study a perfusion technique has been used to investigate jejunal secretion in response to the dibasic amino acid L-arginine. L-arginine at 5, 15, and 40 mmol/l in isotonic saline solutions induced net intestinal secretion of water and Na+. The structurally similar dibasic amino acid L-lysine caused net absorption at 5 and 15 mmol/l, and only modest net secretion of water and Na+ at 40 mmol/l, although absorption rates of the two amino acids were similar. D-arginine (15 mmol/l) was without effect on net water and Na+ absorption. L-arginine 15 mmol/l inhibited glucose-stimulated water and Na+ absorption when perfused in the same intestinal segment, but was without effect when perfused in separate jejunal or ileal segments. Parenteral chlorpromazine inhibited L-arginine induced jejunal water and Na+ secretion. Jejunal secretion induced by L-arginine thus appears not to be due to passive osmotic water flow, nor to release of circulating secretagogues. Stimulation of a mucosal secretory process is most likely to be the mechanism.This publication has 30 references indexed in Scilit:
- Effect of a combination of gastrin, secretin, cholecystokinin, glucagon, and gastric inhibitory polypeptide on jejunal absorption in man.Gut, 1980
- Role of Ca2+-dependent regulator protein in intestinal secretionNature, 1979
- The influence of secretin on ion transport in the human jejunumGut, 1973
- The effect of amino acids and dipeptides on sodium and water absorption in manGut, 1973
- A comparison of stable and 14C-labelled polyethylene glycol as volume indicators in the human jejunumGut, 1972
- The effects of ethanol and chlorpromazine on the passive membrane permeability to Na+Biochimica et Biophysica Acta (BBA) - Biomembranes, 1971
- Further studies on the perfusion method for measuring intestinal absorption in man: The effects of a proximal occlusive balloon and a mixing segmentGut, 1970
- Studies of pancreatic alpha cell function in normal and diabetic subjectsJournal of Clinical Investigation, 1970
- Mechanism of bicarbonate absorption and its relationship to sodium transport in the human jejunumJournal of Clinical Investigation, 1970
- The displacement of membrane calcium by a local anesthetic (chlorpromazine)Biochimica et Biophysica Acta (BBA) - Biomembranes, 1969