TRANSLOCATION OF MINERAL FIBRES THROUGH THE RESPIRATORY SYSTEM AFTER INJECTION INTO THE PLEURAL CAVITY OF RATS
- 1 February 1982
- journal article
- Published by Oxford University Press (OUP) in Annals of Occupational Hygiene
- Vol. 26 (2) , 309-318
- https://doi.org/10.1093/annhyg/26.2.309
Abstract
The translocation of various inorganic fibres (UICC chrysotile A, UICC crocidolite and JM 104 glass fibres) has been studied after their intrapleural injection into rats. Fibres were recovered from all organs removed at necropsy 90 days after injection. The kinetics of the number and mass of fibres recovered from mediastinal lymph nodes were determined. Translocation ratios in terms of number and of mass were calculated for fibres recovered from the lung parenchyma. The mean length of the fibres remaining in the lung parenchyma increased with time for all types of injected fibres. Various possible mechanisms for the clearance of fibres from the pleural cavity are discussed.Keywords
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