The Bacterial Digestion of Tyrosine, Tryptophane and Histidine in Mental Disease

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Abstract
It has often been suggested that functional diseases of the nervous system are caused by intestinal toxæmia, and this suggestion has been revived by certain recent work.Buscaino (1923–26)has described lesions of the small intestine in mental patients which result in undue permeability of its walls. He also describes a toxic substance in the urine in acute confusional and alcoholic insanity and in dementia præcox. This substance is brought down as a black precipitate by silver nitrate in the cold. The liver is deranged in these cases, and decarboxylates amino-acids presented to it instead of deaminizing them.