Neue Antagonisten der Folinsäure

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Abstract
.[long dash]L. J. Daniel and her collaborators have established that only those pterins are antibacterials which possess an amino group in the 6-position. The authors found in the course of work on folic acid synthesis, 2 pterins possessing a hydroxy group in the 6 position, namely 2-amino-6-hydroxypteridine aldehyde-8 and 2-amino-6-hydroxy-8-d-arabotetrahydroxybutylpteridine, which inhibit the growth of Streptococcus faecalis, and are antagonists to folic acid. These two pterins show no growth effect in a folic acid-free medium. In the presence of folic acid, however, they are inhibitory, which action is neutralized in competitive fashion with increasing folic acid concn. However, if one adds to such a culture p-aminobenzoyl-L-glutamic acid, another folic acid precursor, increasing growth is observed with increasing aldehyde concn.; the same is observed after addition of p-aminobenzoic acid but not,however, after that of p-aminobenzoyl-glutathione; the two first mentioned substances therefore are interchangeable. Both substances when added to p-aminobenzoyl-L-glutamic acid appear to produce folic acid; when added to p-aminobenzoic acid, they produce pteroic acid if one proceeds on the basis of certain ideas of Tschesche.